Exploring the cause of sudden unexplained death in epilepsy

Dravet syndrome (DS) is a form of infantile-onset, treatment-resistant epilepsy that is caused by a mutation in the gene encoding a voltage-gated sodium channel, SCN1A. DS patients have a 30-fold increased risk of dying from sudden unexplained death in epilepsy (SUDEP) compared to patients with other forms of pediatric-onset epilepsy. In this issue of the Journal of Clinical Investigation, Franck Kalume and colleagues at the University of Washington characterized SUDEP in a mouse model of DS. Observation using video, electroencephalography, and electrocardiography revealed that a prolonged slowing of the heart beat preceded SUDEP in mice. Treatment with with drugs that reduce activity in the parasympathetic nervous system reduced the incidence of SUDEP, suggesting that mortality results from seizure-related parasympathetic hyperactivity. In a companion Attending Physician, Orrin Devinsky and colleagues discuss how these results could relate to SUDEP in human DS patients.

Exploring the cause of sudden unexplained death in epilepsy

Dravet syndrome (DS) is a form of infantile-onset, treatment-resistant epilepsy that is caused by a mutation in the gene encoding a voltage-gated sodium channel, SCN1A. DS patients have a 30-fold increased risk of dying from sudden unexplained death in epilepsy (SUDEP) compared to patients with other forms of pediatric-onset epilepsy. In this issue of the Journal of Clinical Investigation, Franck Kalume and colleagues at the University of Washington characterized SUDEP in a mouse model of DS. Observation using video, electroencephalography, and electrocardiography revealed that a prolonged slowing of the heart beat preceded SUDEP in mice. Treatment with with drugs that reduce activity in the parasympathetic nervous system reduced the incidence of SUDEP, suggesting that mortality results from seizure-related parasympathetic hyperactivity. In a companion Attending Physician, Orrin Devinsky and colleagues discuss how these results could relate to SUDEP in human DS patients.

(Source: eurekalert.org)

  1. ohwishingflower reblogged this from neuromorphogenesis
  2. ah-thenah reblogged this from medicalexamination
  3. moveoverstyles reblogged this from medicalexamination
  4. c-adaverine reblogged this from medicalexamination
  5. medicalexamination reblogged this from mistressofsurgery
  6. idgaf-lick-my-clit reblogged this from neuromorphogenesis
  7. mistressofsurgery reblogged this from neuromorphogenesis
  8. beegoestomedicalschool reblogged this from neuromorphogenesis
  9. xmushin reblogged this from neuromorphogenesis
  10. hemaris-diffinis reblogged this from sagansense
  11. urielrockrocker reblogged this from neuromorphogenesis
  12. kairi-sea reblogged this from sagansense
  13. laikas-owner reblogged this from sagansense
  14. vaenundt reblogged this from sagansense
  15. thespoopiestsquirrel reblogged this from neuromorphogenesis
  16. sagansense reblogged this from neuromorphogenesis
  17. neuromorphogenesis posted this